Characterization of synovial-derived cells from ostheoarthritic synovium: evidence that macrophages are key effector cells

Published on Apr 1, 2016in Osteoarthritis and Cartilage4.793
· DOI :10.1016/J.JOCA.2016.01.978
C. Manferdini2
Estimated H-index: 2
Cristina Manferdini19
Estimated H-index: 19
+ 4 AuthorsGina Lisignoli37
Estimated H-index: 37
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Cell-to-cell communication has a critical role during tumor development and progression, allowing cancer cell to re-program not only the surrounding tumor microenvironment, but also cells located at distant sites. The crosstalk between neoplastic cells and accessory elements, such as immune and stromal cells, fosters several processes that are necessary for tumor progression and dissemination, such as angiogenesis, immune-escape, epithelial-to-mesenchymal transition, invasion and multi-drug resi...
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#1Cristina ManferdiniH-Index: 19
#2Francesca PaolellaH-Index: 8
Last. Gina LisignoliH-Index: 37
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Summary Objective To define if adipose mesenchymal stromal cell (ASC) treatment mediated switching of the pro-inflammatory profile of M1-like macrophages as a means to develop a tailored in vitro efficacy/potency test. Design We firstly performed immunohistochemical analysis of CD68, CD80 (M1-like) and CD206 (M2-like) macrophages in osteoarthritic (OA) synovial tissue. ASC were co-cultured in contact and in transwell with activated (GM-CSF + IFNγ)-M1 macrophages. We analyzed IL1β, TNFα, IL6, MIP...
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