Characterization of synovial-derived cells from ostheoarthritic synovium: evidence that macrophages are key effector cells

Purpose: Osteoarthritis (OA) is the most common joint disease and the major cause of pain and disability in the aging population. Synovial inflammation is now accepted as important OA feature for the symptoms and disease progression. Synovium is mainly composed of synovial fibroblast (SF) and macrophage (SM) with a low percentage of other cell types. An important key question is which cell types (SF or SM) in OA synovium are responsible for...