Ursolic acid enhances macrophage autophagy and attenuates atherogenesis
Abstract
Macrophage autophagy has been shown to be protective against atherosclerosis. We previously discovered that ursolic acid (UA) promoted cancer cell autophagy. In the present study, we aimed to examine whether UA enhances macrophage autophagy in the context of atherogenesis. Cell culture study showed that UA enhanced autophagy of macrophages by increasing the expression of Atg5 and Atg16l1, which led to altered macrophage function. UA reduced...
Paper Details
Title
Ursolic acid enhances macrophage autophagy and attenuates atherogenesis
Published Date
Jun 1, 2016
Journal
Volume
57
Issue
6
Pages
1006 - 1016
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