The REQUITE-AB study: Validating predictive models and biomarkers of radiotherapy toxicity to reduce side-effects and improve quality of life in breast cancer patients

Background: Clinically significant side-effects from radiotherapy affect around a quarter of breast cancer patients and may have a considerable impact on outcomes from breast surgery. An increasing number of replicated genetic associations for radiotherapy-induced adverse effects are being reported. The purpose of the EU-funded REQUITE consortium is to validate genetic markers and known clinical factors implicated in radiotoxicity to personalise...