Frequency and characterization of benign lesions in patients undergoing surgery for the suspicion of solid pancreatic neoplasm

Published on Nov 1, 2014in Pancreas2.92
· DOI :10.1097/MPA.0000000000000193
Francesco Vitali2
Estimated H-index: 2
,
Torsten Hansen27
Estimated H-index: 27
+ 7 AuthorsLuca Frulloni58
Estimated H-index: 58
Sources
Abstract
ObjectivesA diagnosis of benign lesions (BLs) is reported in 5% to 21% of pancreatoduodenectomies performed for neoplasms; no data for body-tail resections are available. The aims were to investigate the frequency and characterize the BLs mimicking cancer in the head and the body-tail of the pancrea
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#1Phil A. Hart (Mayo Clinic)H-Index: 29
#2Terumi Kamisawa (Tokyo Metropolitan Komagome Hospital)H-Index: 77
Last. Suresh T. Chari (Mayo Clinic)H-Index: 103
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Objective Autoimmune pancreatitis (AIP) is a treatable form of chronic pancreatitis that has been increasingly recognised over the last decade. We set out to better understand the current burden of AIP at several academic institutions diagnosed using the International Consensus Diagnostic Criteria, and to describe long-term outcomes, including organs involved, treatments, relapse frequency and long-term sequelae. Design 23 institutions from 10 different countries participated in this multination...
317 CitationsSource
#1Atsushi Kanno (Tohoku University)H-Index: 39
#1Atsushi KannoH-Index: 18
Last. Tooru ShimosegawaH-Index: 95
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OBJECTIVES: To clarify the clinicoepidemiological features of autoimmune pancreatitis (AIP) in Japan, the nationwide survey was conducted. METHODS: Patients with AIP who had visited the selected hospitals in 2007 were surveyed. Autoimmune pancreatitis was diagnosed according to the Japanese clinical diagnostic criteria 2006. The study consisted of 2-stage surveys: the number of patients with AIP was estimated by the first questionnaire and their clinical features were assessed by the second ques...
89 CitationsSource
#1M. J. van Heerde (Erasmus University Medical Center)H-Index: 2
#2Katharina Biermann (Erasmus University Medical Center)H-Index: 28
Last. H.R. van Buuren (Erasmus University Medical Center)H-Index: 23
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Background Occasionally patients undergoing resection for presumed malignancy of the pancreatic head are diagnosed postoperatively with benign disease. Autoimmune pancreatitis (AIP) is a rare disease that mimics pancreatic cancer. We aimed to determine the prevalence of benign disease and AIP in patients who underwent pancreatoduodenectomy (PD) over a 9-year period, and to explore if and how surgery could have been avoided.
49 CitationsSource
#1Sönke Detlefsen (OUH: Odense University Hospital)H-Index: 21
#2Giuseppe Zamboni (University of Verona)H-Index: 81
Last. Günter Klöppel (TUM: Technische Universität München)H-Index: 38
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Abstract Background At the recent consensus conference on autoimmune pancreatitis (AIP) in Honolulu, we presented preliminary data from our study of surgically treated AIP patients. Our data strongly supported the separation of AIP into type 1 and type 2. Our study is based on a total of 114 surgically treated European AIP patients. Our aims were to elucidate serum IgG4 elevation, other organ involvement, relapse of disease, steroid treatment and diabetes after surgery in 114 surgically treated ...
59 CitationsSource
#1Tae Jun Song (Inje University)H-Index: 7
#1Tae Jun Song (Inje University)H-Index: 27
Last. Eunsil Yu (UOU: University of Ulsan)H-Index: 32
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Background and Aim: Type 2 autoimmune pancreatitis (AIP) has been reported mainly in Western countries and is thought to be very rare in Asia. The aim of this study was to compare the prevalence, clinical profiles, detailed radiological findings, and steroid responsiveness between type 1 and type 2 AIP in Korea. Methods: From 120 patients diagnosed with AIP between January 2003 and August 2010, 52 patients with histologically confirmed type 1 (n = 37) or type 2 (n = 15) AIP were included. Result...
46 CitationsSource
#1Michael Jonathan Hewitt (West Middlesex University Hospital)H-Index: 2
#2M McPhail (West Middlesex University Hospital)H-Index: 1
Last. Kevin J Monahan (West Middlesex University Hospital)H-Index: 11
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Background Preoperative diagnosis of solid pancreatic lesions remains challenging despite advancement in imaging technologies. EUS has the benefit of being a minimally invasive, well-tolerated procedure, although results are operator-dependent. The addition of FNA (EUS-guided FNA) provides samples for cytopathologic analysis, a major advantage over other imaging techniques. Objective To determine the diagnostic accuracy of EUS-FNA for pancreatic cancer. Design This is a meta-analysis of publishe...
409 CitationsSource
#1Terumi Kamisawa (Tokyo Metropolitan Komagome Hospital)H-Index: 77
#2Suresh T. ChariH-Index: 103
Last. Vay Liang W. Go (UCLA: University of California, Los Angeles)H-Index: 93
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: The objective of this study was to clarify the clinical and pathophysiological characteristics of autoimmune pancreatitis (AIP) and its subtypes (lymphoplasmacytic sclerosing pancreatitis [LPSP] and idiopathic duct-centric pancreatitis [IDCP]) seen around the world.: An international multicenter survey of AIP was conducted in 15 institutes from 8 countries. We compared clinical and pathologic profiles of AIP (n = 731) and the clinical profiles of LPSP (n = 204) and IDCP (n = 64) patients.: Pat...
176 CitationsSource
#1Riccardo Manfredi (University of Verona)H-Index: 51
#2Luca FrulloniH-Index: 58
Last. Roberto Pozzi MucelliH-Index: 38
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MR imaging can depict pancreatic abnormalities suggestive of autoimmune pancreatitis at diagnosis and the remission of these abnormalities after steroid therapy, and the bile ducts and the kidneys also may be involved and should be assessed; during follow-up, the risk of recurrence increases with time.
67 CitationsSource
#1Luca Frulloni (University of Verona)H-Index: 58
#2Antonio AmodioH-Index: 13
Last. Italo VantiniH-Index: 36
view all 4 authors...
Autoimmune pancreatitis is a disease characterized by specific pathological features, different from those of other forms of pancreatitis, that responds dramatically to steroid therapy. The pancreatic parenchyma may be diffusely or focally involved with the possibility of a low-density mass being present at imaging, mimicking pancreatic cancer. Clinically, the most relevant problems lie in the diagnosis of autoimmune pancreatitis and in distinguishing autoimmune pancreatitis from pancreatic canc...
31 CitationsSource
#1Tooru Shimosegawa (Tohoku University)H-Index: 95
#2Suresh T. ChariH-Index: 103
Last. Lizhi ZhangH-Index: 54
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Objectives:To achieve the goal of developing international consensus diagnostic criteria (ICDC) for autoimmune pancreatitis (AIP).Methods:An international panel of experts met during the 14th Congress of the International Association of Pancreatology held in Fukuoka, Japan, from July 11 through 13,
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#1Nicolò de PretisH-Index: 8
#2Antonio AmodioH-Index: 13
Last. Luca FrulloniH-Index: 11
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#1Chao Jiang (JLU: Jilin University)H-Index: 4
#2Xueyan Liu (JLU: Jilin University)H-Index: 2
Last. Meng Wang (JLU: Jilin University)H-Index: 3
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Paraduodenal pancreatitis (PP) is a rare type of focal pancreatitis involving the groove space. It mimics pancreatic head carcinoma, and its diagnosis and treatment are challenging. Pancreatoduodenectomy (PD) has traditionally been the primary surgical treatment for duodenal stenosis or suspected cancer.We herein report a case of PP in a 65-year-old man. The patient was admitted to the hospital for postprandial epigastric pain and vomiting. A low-density mass between the uncinate process of the ...
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PURPOSE OF REVIEW Type 2 autoimmune pancreatitis (AIP) is a rare inflammatory disease of the pancreas. Very few data have been published on this particular subtype, which differs from the 'classical' IgG4-related type 1 AIP in terms of pathological features, epidemiology and risk of relapse. The aim of the current review is to summarize the available literature, suggesting a diagnostic and therapeutic approach to this disease. RECENT FINDINGS Based on the International Consensus Diagnostic Crite...
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#1Ivett HegedűsH-Index: 2
#2Barna BognerH-Index: 6
Last. Dezső KelemenH-Index: 9
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Absztrakt: A paraduodenalis, vagy groove pancreatitis egy kevesse ismert kronikus hasnyalmirigygyulladas-tipus, mely malignitast utanozva sokszor differencialdiagnosztikai nehezsegeket okoz. Kozlem...
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#1Roald Flesland Havre (Haukeland University Hospital)H-Index: 23
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Blood-pool ultrasound contrast agents (UCSs) have the ability to image blood flow in soft tissues, which can be visualized at capillary level. Color Doppler has been integrated in EUS equipment since the introduction of electronic transducers and is able to visualize blood flow and its direction in small arteries and veins but not blood flow in capillaries or perfusion. Visualization of perfusion by contrast agents represents a new step in flow imaging and may separate hyper- and hypoperfused ar...
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#2Sébastien Gaujoux (French Institute of Health and Medical Research)H-Index: 42
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Background Accurate preoperative diagnosis is critical for the determination of appropriate surgical indications. The aim of this study was to assess the accuracy of preoperative diagnosis and indications for operative therapy for presumed pancreatic neoplasms. Methods From 2005 to 2013, 851 patients underwent pancreatectomies for presumed pancreatic neoplasms. A formal preoperative diagnosis was established during a multidisciplinary tumor board and compared to the final pathologic examination....
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#1Alexander Schneider (Heidelberg University)H-Index: 32
#2Henrik J. Michaely (Heidelberg University)H-Index: 39
Last. J.-Matthias Löhr (KI: Karolinska Institutet)H-Index: 19
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Abstract Background/Objectives We had developed the Unifying-Autoimmune-Pancreatitis-Criteria (U-AIP) to diagnose autoimmune pancreatitis (AiP) within the M-ANNHEIM classification of chronic pancreatitis. In 2011, International-Consensus-Diagnostic-Criteria (ICDC) to diagnose AiP have been published. We had applied the U-AIP long before the ICDC were available. The aims of the study were, first, to describe patients with AiP diagnosed by the U-AIP; second, to compare diagnostic accuracies of the...
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#1Liang Zhu (Peking Union Medical College Hospital)H-Index: 7
#2Huadan Xue (Peking Union Medical College Hospital)H-Index: 22
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Objectives To determine key MDCT features for characterizing pancreatic neuroendocrine tumours (PNET) from their mimics, which manifest as enhancing pancreatic mass with normal serum CA19-9 level.
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#1Luca Frulloni (University of Verona)H-Index: 58
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Autoimmune pancreatitis (AIP) is a peculiar form of chronic inflammatory disease of the pancreas with unique pathologic features, different from all other forms of pancreatitis. Although a possible autoimmune involvement of the pancreatic gland had been proposed since the early 1960s, the term AIP was introduced in 1995 by Yoshida et al. based on a case report and the review of the available English and Japanese literature. However only in recent years was AIP finally accepted as a distinct noso...
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#1Giulia De Marchi (University of Verona)H-Index: 6
#2Salvatore Paiella (University of Verona)H-Index: 23
Last. Luca Frulloni (University of Verona)H-Index: 58
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