Tristetraprolin (TTP) coordinately regulates primary and secondary cellular responses to proinflammatory stimuli

Volume: 97, Issue: 4, Pages: 723 - 736
Published: Feb 5, 2015
Abstract
TTP is an anti-inflammatory protein that acts by binding to AREs in its target mRNAs, such as Tnf mRNA, and promoting their deadenylation and decay. TNF released from inflammatory cells can then stimulate gene expression in tissue cells, such as fibroblasts. To determine whether TTP could affect the decay of TNF-induced transcripts in fibroblasts, we exposed primary embryonic fibroblasts and stable fibroblast cell lines, derived from WT and TTP...
Paper Details
Title
Tristetraprolin (TTP) coordinately regulates primary and secondary cellular responses to proinflammatory stimuli
Published Date
Feb 5, 2015
Volume
97
Issue
4
Pages
723 - 736
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