Effect of chlorination on the distribution and excretion of polychlorinated biphenyls.

The distribution and excretion of four 14C-labeled polychlorinated biphenyls (PCB), 4-chloro-, 4,4'-dichloro-, 2,4,5,2',5'-pentachloro-, and 2,4,5,2',4',5'-hexachlorobiphenyl, were studied in the rat. Total radioactivity was determined in the major organs and tissues at times varying from 15 min up to 42 days after an intravenous injection of a single 0.6-mg dose of each of the PCB's per kg. Each of the PCB's was removed rapidly from the blood...