Hormonal therapy in prostate cancer: historical approaches.

Hormonal therapy has been the standard of care for advanced prostate cancer for over 6 decades. Treatments to suppress testosterone have expanded beyond surgical castration and estrogens to include steroidal and nonsteroidal antiandrogens, luteinizing hormone-releasing hormone agonists, and, most recently, gonadotropin-releasing hormone antagonists. Yet, despite this extensive therapeutic armamentarium, long-term survival of patients with...