Repositioning Clofazimine as a Macrophage-Targeting Photoacoustic Contrast Agent
Abstract
Photoacoustic Tomography (PAT) is a deep-tissue imaging modality, with potential clinical applications in the diagnosis of arthritis, cancer and other disease conditions. Here, we identified Clofazimine (CFZ), a red-pigmented dye and anti-inflammatory FDA-approved drug, as a macrophage-targeting photoacoustic (PA) imaging agent. Spectroscopic experiments revealed that CFZ and its various protonated forms yielded optimal PAT signals at...
Paper Details
Title
Repositioning Clofazimine as a Macrophage-Targeting Photoacoustic Contrast Agent
Published Date
Mar 22, 2016
Journal
Volume
6
Issue
1
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