Topographic Profiles of Retinal Nerve Fiber Layer Defects Affect the Diagnostic Performance of Macular Scans in Preperimetric Glaucoma

Purpose.: To evaluate the influence of topographic profiles (i.e., inner directional angle and angular width) of localized retinal nerve fiber layer (RNFL) defects on the diagnostic performance of macular ganglion cell–inner plexiform layer (GCIPL) thickness in discriminating preperimetric glaucoma (PPG) eyes from normal control eyes. Methods.: The ganglion cell analysis algorithm in Cirrus OCT was performed to determine the macular GCIPL...