INVOLVEMENT OF NITRIC OXIDE IN CLONIDINE-INDUCED SPINAL ANALGESIA

The chronic pain relieving effects following spinal administration of clonidine are probably connected to alpha2-adrenoreceptor-induced augmented synthesis of nitric oxide (NO) in the spinal cord. In contrast, when acute pain is considered, the possible role of NO is still speculative. The aim of the present study was to explore the role of NO in acute pain relief following intraspinal administration of clonidine.We used the mouse tail-flick...