The Effects of Hormonotherapy Following Concomitant Use of Trastuzumab and Radiation Therapy on Late Skin Toxicity

To investigate whether hormonotherapy followed by concomitant use of trastuzumab (T) and radiation therapy (RT) contributes to the development of radiation-induced skin fibrosis. 70 healthy female rats divided into seven groups: Control group (C) underwent no procedure. RT group underwent thoracic radiation (TR). T group was administered T. T+RT+Tx group was administered concomitant T and TR, followed by tamoxifen. T+RT+Le group was administered...