ADAM17 Inhibitors Attenuate Corneal Epithelial Detachment Induced by Mustard Exposure
Volume: 57, Issue: 4, Pages: 1687 - 1687
Published: Apr 8, 2016
Abstract
Purpose: Sulfur mustard, nitrogen mustard (NM), and 2-chloroethyl ethyl sulfide all cause corneal injury with epithelial–stromal separation, differing only by degree. Injury can resolve in a few weeks or develop into chronic corneal problems. These vesicants induce microbullae at the epithelial–stromal junction, which is partially caused by cleavage of transmembranous hemidesmosomal collagen XVII, a component anchoring the epithelium to the...
Paper Details
Title
ADAM17 Inhibitors Attenuate Corneal Epithelial Detachment Induced by Mustard Exposure
Published Date
Apr 8, 2016
Volume
57
Issue
4
Pages
1687 - 1687
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