Linker Technology in Antibody-Drug Conjugates for Cancer Treatment
Abstract
抗体―抗がん剤複合体においては、抗体と抗がん剤を結合するリンカーが重要な役割を持つ。リンカーは、抗体―抗がん剤複合体を血中では安定に保持する一方、疾病部において、薬物を放出するはたらきを持つ。本稿では、リンカーおよびリンカーの構成部分であるスペーサーの種類と特徴について述べる...
Paper Details
Title
Linker Technology in Antibody-Drug Conjugates for Cancer Treatment
Published Date
Jan 1, 2013
Journal
Volume
28
Issue
5
Pages
406 - 411
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Notes
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