HER2 in Breast Cancer
Abstract
HER2 (human epidermal growth factor receptor 2) receptor is a membrane tyrosine kinase and when activated affects cell proliferation and survival. The HER2 oncogene is located on chromosome 17q12. HER2 amplification is the primary pathway of HER2 receptor overexpression and is a major driver of tumor development and progression in a subset of breast cancers. HER2 is amplified in about 15% to 20% of breast cancers. The overexpressed HER2 receptor...
Paper Details
Title
HER2 in Breast Cancer
Published Date
Mar 1, 2014
Volume
21
Issue
2
Pages
100 - 107
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