The Bronchoconstrictor Effect of Inhaled Prostaglandin D2 in Normal and Asthmatic Men

Although prostaglandin D2 is the most abundant prostanoid generated by human lung mast cells and causes bronchoconstriction in animals, its effects have not been studied in human beings. We have compared the effects of inhaled prostaglandin D2 and prostaglandin F2α on specific airway conductance in seven normal subjects and seven patients with mild allergic asthma. In dose–response studies in normal subjects, prostaglandin D2 caused a...