Abnormal fetal-maternal interactions: an evolutionary value?

Published on Aug 1, 2012in Obstetrics & Gynecology7.661
· DOI :10.1097/AOG.0B013E31825CB96D
Jimmy Espinoza78
Estimated H-index: 78
(Beaumont Hospital)
Sources
Abstract
There is clinical and ultrasonographic evidence that “abnormal fetal–maternal interactions” or “fetal–maternal conflicts” may be central to the mechanisms of injury in pregnancy complications such as fetal growth restriction, preeclampsia, fetal death, gestational diabetes, and a subset of patients
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References18
Newest
#1Eleazar Soto (NIH: National Institutes of Health)H-Index: 24
#2Roberto Romero (NIH: National Institutes of Health)H-Index: 181
Last. Tinnakorn ChaiworapongsaH-Index: 88
view all 9 authors...
Objective: An imbalance between maternal angiogenic/anti-angiogenic factors concentrations has been observed in preeclampsia (PE) and other obstetrical syndromes. However, the frequency of pathologic findings in the placenta and the changes in maternal plasma angiogenic/anti-angiogenic factor concentrations differ between late- and early-onset PE. The aim of this study was to determine if the maternal plasma concentrations of placental growth factor (PlGF), soluble endoglin (sEng), and soluble v...
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#1Laura Avagliano (University of Milan)H-Index: 20
#2Gaetano BulfamanteH-Index: 31
Last. Anna Maria MarconiH-Index: 36
view all 4 authors...
Introduction Modification of the spiral arteries with loss of the muscular vascular wall, invaded by the trophoblasts, represents the goal of the physiological vascular adaptation during human implantation. When physiological vascular changes do not occur, an unfavourable evolution of gestation may develop as suggested by uterine biopsies studies. Aims To evaluate the prevalence of the abnormal spiral arteries modification (ASAM) through the routine examination of placentas, to identify maternal...
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#1Sangeeta Pathak (Cambridge University Hospitals NHS Foundation Trust)H-Index: 7
#2Christoph Lees (Cambridge University Hospitals NHS Foundation Trust)H-Index: 54
Last. Neil J. Sebire (GOSH: Great Ormond Street Hospital)H-Index: 100
view all 5 authors...
Associations between specific placental histological abnormalities and obstetric outcomes are reported. However, most data are based either on high-risk cases or relate to case–control studies selected from those with abnormal placental histology findings, with the unavoidable biases that these approaches entail. This study reports the frequency of the several common, objective and predefined histological abnormalities of the placenta as identified by pathologists blinded to all clinical informa...
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#1Giovanna Ogge (NIH: National Institutes of Health)H-Index: 18
Last. Sonia S. HassanH-Index: 92
view all 8 authors...
Preeclampsia (PE) has been classified into early- and late-onset disease. These two phenotypic variants of PE have been proposed to have a different pathophysiology. However, the gestational age cut-off to define "early" vs. "late" PE has varied among studies. The objective of this investigation was to determine the prevalence of lesions consistent with maternal underperfusion of the placenta in patients with PE as a function of gestational age.A nested case-control study of 8307 singleton pregn...
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#1Jimmy Espinoza (Beaumont Hospital)H-Index: 78
#2John E. Uckele (Beaumont Hospital)H-Index: 3
Last. Stanley M. Berry (Beaumont Hospital)H-Index: 33
view all 6 authors...
Clinical and experimental evidence indicates that angiogenic imbalances may participate in the mechanisms of disease of several pregnancy complications, some of which may be life threatening. This article reviews current evidence in support of this view and the possibility that the fetus may play a central role in these imbalances; it also reviews recent experimental observations that modulation of angiogenic imbalances during pregnancy may have prophylactic and/or therapeutic value.
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#1Robert Pijnenborg (Katholieke Universiteit Leuven)H-Index: 43
#2Lisbeth Vercruysse (Katholieke Universiteit Leuven)H-Index: 23
Last. Myriam Hanssens (Katholieke Universiteit Leuven)H-Index: 27
view all 3 authors...
The much publicized conflict hypothesis for understanding fetal-maternal interaction during pregnancy often invokes a ‘battle’ metaphor, rather than a well orchestrated interplay occurring as a series of well controlled moves and counter-moves as happens in a game of chess. Such stepwise interaction is particularly obvious in the spiral artery remodelling process, and it would be interesting to trace the history of the successive steps in histological adaptation throughout primate phylogeny. The...
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#1Robert Pijnenborg (Katholieke Universiteit Leuven)H-Index: 43
#2Lisbeth Vercruysse (Katholieke Universiteit Leuven)H-Index: 23
Last. Myriam Hanssens (Katholieke Universiteit Leuven)H-Index: 27
view all 3 authors...
Uterine spiral arteries play a vital role in supplying nutrients to the placenta and fetus, and for this purpose they are remodelled into highly dilated vessels by the action of invading trophoblast (physiological change). Knowledge of the mechanisms of these changes is relevant for a better understanding of pre-eclampsia and other pregnancy complications which show incomplete spiral artery remodelling. Controversies still abound concerning different steps in these physiological changes, and sev...
Source
#1Yariv Yogev (University of Texas Health Science Center at San Antonio)H-Index: 51
#2Elly M J Xenakis (Columbia University)H-Index: 23
Last. Oded Langer (Columbia University)H-Index: 7
view all 3 authors...
Abstract Objectives We sought to determine if the rate of preeclampsia is related to the severity of gestational diabetes mellitus (GDM), and if it can be decreased by optimizing glycemic control. Study design A retrospective analysis of prospectively collective data of 1813 patients with GDM was performed to determine the rate of preeclampsia. Patients were stratified after treatment was begun by level of glycemic control (well controlled was defined as mean blood glucose Results Overall, preec...
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#1Ingrid Östlund (Uppsala University)H-Index: 4
#2Bengt Haglund (Uppsala University)H-Index: 29
Last. Ulf Hanson (Uppsala University)H-Index: 28
view all 3 authors...
Objective: To determine whether gestational diabetes mellitus (GDM) increases the risk for preeclampsia independent of other risk factors. Study design: The association between GDM and preeclampsia was analyzed in a population of women who had given birth to singletons registered in Swedish Medical Birth Register from 1992 through 1996 (n=430,852). Results: GDM occurred in 0.8% and preeclampsia in 2.9% of all pregnancies. The rate of preeclampsia was higher in the GDM than in the non-GDM group (...
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Abstract To investigate the function of the Grb10 adapter protein, we have generated mice in which the Grb10 gene was disrupted by a gene-trap insertion. Our experiments confirm that Grb10 is subject to genomic imprinting with the majority of Grb10 expression arising from the maternally inherited allele. Consistent with this, disruption of the maternal allele results in overgrowth of both the embryo and placenta such that mutant mice are at birth ≈30% larger than normal. This observation establi...
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Cited By5
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#1Ji Hyae LimH-Index: 17
Last. Hyun Mee RyuH-Index: 17
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Preeclampsia (PE) is an obstetric disorder with significant morbidities for both the mother and fetus possibly caused by a failure of the placental trophoblast invasion. However, its pathophysiology largely remains unclear. Here, we performed DNA methylation profiling to determine whether differential patterns of DNA methylation correlate with PE and severe features of PE. We extracted DNA from placental tissues of 13 normal, five PE, and eight PE pregnant women with severe features. Genome-wide...
Source
#1Amin Kamrani (Tabriz University of Medical Sciences)H-Index: 9
#2Iraj Alipourfard (University of Vienna)H-Index: 5
Last. Majid Ahmadi (Tabriz University of Medical Sciences)H-Index: 23
view all 7 authors...
: Preeclampsia (PE) is a disorder affecting 2-10% of pregnancies and has a major role for perinatal and maternal mortality and morbidity. PE can be occurred by initiation of new hypertension combined with proteinuria after 20 weeks gestation, as well as various reasons such as inflammatory cytokines, poor trophoblast invasion can be related with PE disease. Environmental factors can cause epigenetic changes including DNA methylation, microRNAs (miRNAs), and histone modification that may be relat...
Source
#1Kristen R Yeung (USYD: University of Sydney)H-Index: 5
#2Christine L Chiu (USYD: University of Sydney)H-Index: 16
Last. Joanne M. Lind (USYD: University of Sydney)H-Index: 16
view all 6 authors...
This study identified novel gene-specific differences in DNA methylation in preeclampsia-affected placentas. These results improve our understanding of the pathophysiological disease process, including the involvement of cell signaling, fertilization and implantation, reactive oxygen species signaling, and cell adhesion.
Source
#1Ignacio Herraiz (Complutense University of Madrid)H-Index: 22
#2Elisa Simón (Complutense University of Madrid)H-Index: 4
Last. Alberto Galindo (Complutense University of Madrid)H-Index: 29
view all 7 authors...
Placental dysfunction is involved in a group of obstetrical conditions including preeclampsia, intrauterine growth restriction, and placental abruption. Their timely and accurate recognition is often a challenge since diagnostic criteria are still based on nonspecific signs and symptoms. The discovering of the role of angiogenic-related factors (sFlt-1/PlGF) in the underlying pathophysiology of placental dysfunction, taking into account that angiogenesis-related biomarkers are not specific to an...
Source
#1Alex C. Vidaeff (BCM: Baylor College of Medicine)H-Index: 16
#2Manju Monga (BCM: Baylor College of Medicine)H-Index: 23
Last. Haleh Sangi-Haghpeykar (BCM: Baylor College of Medicine)H-Index: 30
view all 5 authors...
Objective To determine the relation between thrombin generation (measured by thrombin-antithrombin [TAT] complexes) early in pregnancy and subsequent preterm delivery. Study Design Select cohort of 731 women undergoing indicated second trimester amniocentesis prospectively followed to delivery. Primary outcome was preterm delivery. TAT levels were examined continuously and categorized by quartiles. Multivariable techniques were applied to adjust for potential confounders. Receiver operating char...
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