Developing Cancer Immunotherapies by the manipulation of Immune Checkpoints

–A tumor mass consists of cells that have undergone a large number of mutations, these mutations might provide a diverse set of antigens that are capable of producing an immune response. Therefore cancer cells need to suppress the immune system to form a sustainable tumor mass. Hence, tumors co-opt certain immune checkpoint pathways to suppress the immune response in the tumor microenvironment. Immune checkpoints are the inhibitory pathways used...