SAT0247 Increased methylation status of SOX9 gene promoter in human osteoarthritic cartilage

Background

Osteoarthritis (OA) is a chronic degenerative joint disorder of high prevalence that remains the leading cause of disability in aged people. A balance between anabolic and catabolic mechanisms maintains extracellular matrix homeostasis in articular cartilage. Among mechanisms to control gene expression, genomic DNA methylation, modification of nucleosome histone tails, and chromosome remodeling are essential contributors to...