Abstract IA5: The role of nitric oxide in the tumor microenvironment

Tumor blood vessels exhibit abnormal organization, structure, and function characterized by heterogeneous and at times compromised blood flow, and hyperpermeability. Furthermore, intra-tumoral lymphatics are not functional even if they exist and peritumoral lymphatics are dysfunctional. Collectively, these abnormalities result in a hostile tumor microenvironment, which hinders the delivery and efficacy of therapeutic agents, and also promotes a...