Living with untreated prostate cancer: predictors of quality of life.

Published on May 1, 2014in Current Opinion in Urology2.152
· DOI :10.1097/MOU.0000000000000038
Lara Bellardita10
Estimated H-index: 10
Silvia Villa6
Estimated H-index: 6
Riccardo Valdagni51
Estimated H-index: 51
Purpose of reviewTo summarize the literature on the predictors of quality of life (QoL) of patients with prostate cancer (PCa) on active surveillance and to highlight both risk factors of poor QoL and resilience factors that facilitate decision-making and promote adherence to active surveillance.Rec
#1Dean Ornish (UCSF: University of California, San Francisco)H-Index: 34
#2Jue Lin (UCSF: University of California, San Francisco)H-Index: 55
Last. Elizabeth H. Blackburn (UCSF: University of California, San Francisco)H-Index: 119
view all 15 authors...
Summary Background Telomere shortness in human beings is a prognostic marker of ageing, disease, and premature morbidity. We previously found an association between 3 months of comprehensive lifestyle changes and increased telomerase activity in human immune-system cells. We followed up participants to investigate long-term effects. Methods This follow-up study compared ten men and 25 external controls who had biopsy-proven low-risk prostate cancer and had chosen to undergo active surveillance. ...
244 CitationsSource
#1Lara BellarditaH-Index: 10
#2Riccardo ValdagniH-Index: 51
Last. Tiziana RancatiH-Index: 27
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1 CitationsSource
#1Laurence Klotz (Sunnybrook Health Sciences Centre)H-Index: 85
Cancer is a dreaded disease in the publicmind, and learning that one is diagnosed is a stressful and anxiety-laden experience. The diagnosis of prostate cancer induces a range of psychosocial responses in men and their families. The responses to a cancer diagnosis, like responses to any major stressor, reflect many factors including a patient’s upbringing, personality, and social support and environment. Men diagnosed with prostate cancer in late middle age may have their response conditioned by...
24 CitationsSource
#1Lara BellarditaH-Index: 10
#2Tiziana RancatiH-Index: 27
Last. Riccardo ValdagniH-Index: 51
view all 11 authors...
Abstract Background Active surveillance (AS) is emerging as an alternative approach to limit the risk of overtreatment and impairment of quality of life (QoL) in patients with low-risk localised prostate cancer. Although most patients report high levels of QoL, some men may be distressed by the idea of living with untreated cancer. Objective To identify factors associated with poor QoL during AS. Design, setting, and participants Between September 2007 and March 2012, 103 patients participated i...
78 CitationsSource
#1Andrea Tavlarides (Mayo Clinic)H-Index: 4
#2Steven C. Ames (Mayo Clinic)H-Index: 17
Last. Alexander S. Parker (Mayo Clinic)H-Index: 35
view all 8 authors...
Background Cancer-specific anxiety (CSA) can affect treatment decisions and is common in men following surgery for prostate cancer (PCa). We hypothesized that CSA is also associated with factors affecting quality of life. Herein, we examine the association of CSA with psychosocial factors and PCa aggressiveness in a cohort of men 1 year after prostatectomy for localized PCa. Methods From our prospective PCa Registry, we identified 365 men who underwent prostatectomy for localized PCa who complet...
33 CitationsSource
Purpose of reviewTo summarize the evidence, now extensive, that efforts to reduce prostate cancer mortality by screening and early detection result in overdiagnosis of disease that is clinically insignificant, and would never have been diagnosed in the patient's lifetime in the absence of screening.
91 CitationsSource
#1Meredith Wallace Kazer (Fairfield University)H-Index: 11
#2Sarah P. Psutka (Harvard University)H-Index: 19
Last. Donald E. Bailey (Duke University)H-Index: 26
view all 4 authors...
PURPOSE OF REVIEW: To summarize the literature on psychosocial responses to active surveillance as well as educational and support strategies to promote adherence. RECENT FINDINGS: There are two prevalent responses among men undergoing active surveillance; anxiety and uncertainty. The education of a patient about low-risk prostate cancer as well as the inquiry by the physician into patient's priorities and goals with respect to their prostate cancer diagnosis provide opportunities to facilitate ...
27 CitationsSource
#1Suzanne K. Chambers (Griffith University)H-Index: 55
#2Megan Ferguson (Cancer Council Queensland)H-Index: 14
Last. Stefano Occhipinti (Griffith University)H-Index: 29
view all 5 authors...
Background Prostate cancer is the most common cancer in men in the Western world with well-described negative effects from treatments. However, outcomes are highly heterogeneous. A Phase 3 trial of a psycho-educational intervention was undertaken, aiming to reduce cancer-specific and decision-related distress and improve quality of life for men newly diagnosed with localised prostate cancer. Methods Seven hundred forty (81.7%) men were recruited after diagnosis and before treatment and randomise...
57 CitationsSource
#1Meelan Bul (EUR: Erasmus University Rotterdam)H-Index: 11
#1Samir S. Taneja (EUR: Erasmus University Rotterdam)H-Index: 1
Last. Monique J. Roobol (EUR: Erasmus University Rotterdam)H-Index: 29
view all 20 authors...
Abstract Background Overdiagnosis and subsequent overtreatment are important side effects of screening for, and early detection of, prostate cancer (PCa). Active surveillance (AS) is of growing interest as an alternative to radical treatment of low-risk PCa. Objective To update our experience in the largest worldwide prospective AS cohort. Design, setting, and participants Eligible patients had clinical stage T1/T2 PCa, prostate-specific antigen (PSA) ≤10 ng/ml, PSA density Reclassification was ...
391 CitationsSource
#1Chris H. Bangma (EUR: Erasmus University Rotterdam)H-Index: 78
#2Meelan Bul (EUR: Erasmus University Rotterdam)H-Index: 11
Last. Riccardo ValdagniH-Index: 51
view all 23 authors...
There is strong evidence that low risk and many cases of low-intermediate risk prostate cancer are indolent, have little or no metastatic potential, and do not pose a threat to the patient in his lifetime (clinically insignificant). We have made major strides in understanding who these patients are, and in counseling the use of conservative management in such individuals. A key component of this approach is the early identification of those “low risk” patients who harbor higher risk disease, and...
69 CitationsSource
Cited By9
#1Nigel P MurrayH-Index: 9
#1Nigel P MurrayH-Index: 2
Last. Eduardo ReyesH-Index: 8
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OBJECTIVE: It has been reported that the systemic immune-inflammation index (SII) and platelet-to-lymphocyte ratio (PLR) are higher in men with prostate cancer. We compare their use with the percentage of free prostate-specific antigen (PSA), PSA density, and primary circulating prostate cells (CPCs) to predict clinically significant prostate cancer at first biopsy in men with a PSA of 4-10 ng/mL. MATERIAL AND METHODS: Consecutive men with suspicion of prostate cancer underwent a 12-core transre...
3 CitationsSource
Background Previous quality of life (QoL) literature in bladder cancer (BC) patients has focused on finding the preferred urinary diversion while little is known about the QoL of patients in medical oncological treatment (MOT). We performed a systematic review to assess the existing literature on QoL in patients with muscle-invasive BC (MIBC) undergoing MOT.
16 CitationsSource
Prostate cancer (PCa) patients selected for active surveillance (AS) have received information on prostate cancer PCa, treatment, knew their serum prostate speci c antigen (PSA), a digital rectal examination (DRE) done and could rely on their set of biopsies to be labelled as low grade, low volume disease (by adding a radiographic/ultrasonic measurement). They usually react euphoric to the selection hoping to escape invasive curative treatment and its side-effects. Unfortunately, this positive f...
2 CitationsSource
#1Lara BellarditaH-Index: 10
#2Paola DordoniH-Index: 2
Last. Riccardo Valdagni (University of Milan)H-Index: 51
view all 5 authors...
The journey of men diagnosed with low-volume, potentially non-aggressive prostate cancer may be a multifaceted one. In fact, from the moment of diagnosis, patients deal with the opportunity and burden of choosing among multiple therapeutic/observational strategies that differ in terms of clinical and personal costs and benefits. The treatment/active surveillance decision can be an initially counterintuitive one and feelings of disorientation could emerge. Based on existing literature and our exp...
1 CitationsSource
#1Eeva Harju (UTA: University of Tampere)H-Index: 3
#2Anja Rantanen (UTA: University of Tampere)H-Index: 7
Last. Päivi Åstedt-Kurki (UTA: University of Tampere)H-Index: 36
view all 6 authors...
Aims To describe the health-related quality of life (HRQOL) of patients with prostate cancer and their spouses in comparison with the Finnish general population, using the RAND 36-Item Health Survey. An additional purpose was to describe the associations between the background variables of the participants and their HRQOL. Background The HRQOL of patients with prostate cancer and especially their spouses at the time of diagnosis is not well known. Design A cross-sectional study. Methods Response...
4 CitationsSource
#1John S. BanerjiH-Index: 5
#2Lauren M. Hurwitz (Henry M. Jackson Foundation for the Advancement of Military Medicine)H-Index: 9
Last. Christopher R. PorterH-Index: 24
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Abstract Introduction Patients with low-risk prostate cancer (PCa) often have excellent oncologic outcomes. However, treatment with curative intent can lead to decrements in health-related quality of life (HRQoL). Patients treated with radical prostatectomy have been shown to suffer declines in urinary and sexual HRQoL as compared to those managed with active surveillance (AS). Similarly, patients treated with external-beam radiation therapy (EBRT) are hypothesized to experience greater declines...
7 CitationsSource
#1Silvia VillaH-Index: 6
#2Friederike KendelH-Index: 16
Last. Lara BellarditaH-Index: 10
view all 19 authors...
Abstract Background Literature on the health-related quality of life (HRQoL) for men with localized prostate cancer (PCa) on active surveillance (AS) shows a need for methodological guidance regarding HRQoL issues and how to address them. Objective The European School of Oncology Task Force (ESO TF) aimed to identify a core set of research questions and related measures to include in AS HRQoL studies. Design, setting, and participants A modified Delphi study was used to reach consensus on AS HRQ...
8 CitationsSource
#1Lara BellarditaH-Index: 10
#2Riccardo ValdagniH-Index: 51
Last. Ida J. Korfage (Erasmus University Medical Center)H-Index: 36
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Abstract Context The optimal management of screen-detected, localised prostate cancer remains controversial, related to overtreatment issues of screening and the nonrandomised evidence base. Active surveillance (AS) aims to delay or avoid curative therapy but may potentially harm patients' well-being through living with untreated prostate cancer. Objective To systematically review the literature on quality of life (QoL) in patients undergoing AS. Evidence acquisition Embase, Medline, Psychinfo, ...
91 CitationsSource
#1Axel HeidenreichH-Index: 72
#2Joaquim BellmuntH-Index: 87
Last. Filiberto ZattoniH-Index: 28
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620 Citations