Intranasal Fluorescent Nanocrystals for Longitudinal In Vivo Evaluation of Cerebral Microlesions

Current neuroimaging techniques in experimental medicine and clinical diagnosis are limited by low resolution and restricted image depth. Fluorescence in vivo imaging using near-infrared-emitting nanostructures, including nanocrystal quantum dots (QDs) can overcome these limitations. The objective of the present study was to establish if nanocrystals are suitable for repeated live imaging of deep structures (500 µm) in the intact animal....