Neurocognitive assessment in the diagnosis of HIV-associated neurocognitive disorders.

Published on Feb 1, 2014in Seminars in Neurology3.42
路 DOI :10.1055/S-0034-1372339
Kevin Robertson59
Estimated H-index: 59
(UNC: University of North Carolina at Chapel Hill),
Sarah Yosief3
Estimated H-index: 3
(UNC: University of North Carolina at Chapel Hill)
Sources
Abstract
Neurocognitive assessment plays a central role in the diagnosis of human immunodeficiency virus- (HIV) associated neurocognitive disorders (HAND). The history of diagnostic categories and labeling of HIV-related neurological disorders is briefly presented. The current diagnostic nomenclature of HAND and the role of neurocognitive assessment is examined. Though neurocognitive testing is sensitive in assessing a broad range of cognitive impairments, neurocognitive testing is not specific to HAND without consideration of the impact on functional status, as well as confounding factors, including premorbid status.
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#2Kaundinya Gopinath (Emory University)H-Index: 16
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Central nervous system (CNS) sequelae continue to be common in HIV-infected individuals despite combination antiretroviral therapy (cART). These sequelae include HIV-associated neurocognitive disorder (HAND) and virologic persistence in the CNS. Resting state functional magnetic resonance imaging (rsfMRI) is a widely used tool to examine the integrity of brain function and pathology. In this study, we examined 16 HIV-positive (HIV+) subjects and 12 age, sex, and race matched HIV seronegative con...
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#1Shivesh Ghura (UPenn: University of Pennsylvania)H-Index: 2
#2Robert E. Gross (UPenn: University of Pennsylvania)H-Index: 84
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#1Beret Amundson (Emory University)H-Index: 1
#2Lillin Lai (NYU: New York University)H-Index: 1
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#1Amila Omeragic (U of T: University of Toronto)H-Index: 4
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HIV associated neurocognitive disorders (HAND) are the spectrum of cognitive impairments present in patients infected with human immunodeficiency virus type 1 (HIV-1). The number of patients affected with HAND ranges from 30 to 50% of HIV infected individuals and although the development of combinational antiretroviral therapy (cART) has improved longevity, HAND continues to pose a significant clinical problem as the current standard of care does not alleviate or prevent HAND symptoms. At presen...
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#6Benjamin B. Gelman (UTMB: University of Texas Medical Branch)H-Index: 24
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HIV-associated neurocognitive disorder (HAND) is a common condition in both developed and developing nations, but its cause is largely unknown. Previous research has inconsistently linked Alzheimer鈥檚 disease (AD), viral burden, and inflammation to the onset of HAND in HIV-infected individuals. Here we simultaneously measured cerebrospinal fluid (CSF) levels of established amyloid and tau biomarkers for AD, viral copy numbers, and six key cytokines in 41 HIV-infected individuals off combination a...
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HIV-associated neurocognitive disorder (HAND) persists in the combination antiretroviral therapy (cART) era and is associated with diminished quality of life. The disorder remains challenging to diagnose given the requirement for comprehensive neuropsychological testing. Blood biomarkers are needed to facilitate the diagnosis of HAND and to gauge neurological response to antiretroviral therapy. We performed a study of plasma neurofilament light chain (NFL) that included 37 HIV-infected and 54 HI...
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