The Role of Endocytic Pathways on Estrogen Receptor α Intracellular Trafficking and 17β-estradiol Signaling

Published on Apr 8, 2015in Immunology‚ Endocrine & Metabolic Agents in Medicinal Chemistry
· DOI :10.2174/1871522214666141029234030
Valeria Pesiri7
Estimated H-index: 7
Pierangela Totta16
Estimated H-index: 16
Filippo Acconcia30
Estimated H-index: 30
📖 Papers frequently viewed together
9 Citations
1 Author (Ning Li)
119 Citations
Cited By1
#1Pierangela TottaH-Index: 16
#2Valeria PesiriH-Index: 7
Last. Filippo AcconciaH-Index: 30
view all 5 authors...
17β-estradiol (E2)-induced signaling and control of estrogen receptor (ER)α degradation both play a major role in breast cancer cell proliferation. We recently reported the involvement of lysosomal function in both E2-dependent ERα breakdown and E2-induced cell proliferation and thus hypothesized a role for endocytic proteins in ERα signaling. An small interfering RNA screen identified proteins that regulate intracellular endocytic traffic and whose silencing alters E2-induced ERα degradation. O...
15 CitationsSource