Estrogen/Huntingtin: a novel pathway involved in neuroprotection

Neurodegenerative diseases (NDs) include more than 600 disease entities that are characterized by loss of specific neurons located in anatomically related functional areas which progressively lead to motor and cognitive deficits. The pathogenesis of NDs involves mitochondrial dysfunction/oxidative stress, programmed cell death or abnormal protein aggregation, trafficking, and/or degradation. In most cases, the end stage neuropathology is...