Pulmonary Hypertension in Congenital Heart Disease 121

The state of the pulmonary vascular bed impacts on the outcome of CHD. Both active vasoconstriction and pathological remodeling conspire to increase PVR. The combination of increased pulmonary blood flow and pulmonary artery pressure is a potent stimulator of pulmonary vascular disease. With the exception of a few high-risk malformations (e.g., d-TGA and VSD), permanent or progressive pathological changes seldom occur when malformations are...