Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization

Volume: 6, Issue: 1, Pages: 23372 - 23372
Published: Mar 18, 2016
Abstract
Glioblastoma multiforme (GBM) is the most common malignant brain tumor with a median survival time about one year. Invasion of GBM cells into normal brain is the major cause of poor prognosis and requires dynamic reorganization of the actin cytoskeleton, which includes lamellipodial protrusions, focal adhesions, and stress fibers at the leading edge of GBM. Therefore, we hypothesized that inhibitors of actin polymerization can suppress GBM...
Paper Details
Title
Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization
Published Date
Mar 18, 2016
Volume
6
Issue
1
Pages
23372 - 23372
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