Targeting CDK4/6 in patients with cancer
Abstract
The cyclin D-cyclin dependent kinase (CDK) 4/6-inhibitor of CDK4 (INK4)-retinoblastoma (Rb) pathway controls cell cycle progression by regulating the G1-S checkpoint. Dysregulation of the cyclin D-CDK4/6-INK4-Rb pathway results in increased proliferation, and is frequently observed in many types of cancer. Pathway activation can occur through a variety of mechanisms, including gene amplification or rearrangement, loss of negative regulators,...
Paper Details
Title
Targeting CDK4/6 in patients with cancer
Published Date
Apr 1, 2016
Journal
Volume
45
Pages
129 - 138
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Notes
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