Chetomin, targeting HIF-1α/p300 complex, exhibits antitumour activity in multiple myeloma

Multiple myeloma (MM) is an incurable clonal plasma cell malignancy. The constitutive expression of HIF-1α in MM suggests that inhibition of HIF-1α-mediated transcription represents an interesting target in MM. As p300 is a crucial co-activator of hypoxia-inducible transcription, disrupting the complex HIF-1α/p300 to target HIF activity appears to be an attractive strategy. We reported that chetomin, an inhibitor of HIF-1α/p300 interaction,...