New developments for antibody-drug conjugate-based therapeutic approaches

Published on Jun 1, 2016in Current Opinion in Immunology7.29
· DOI :10.1016/J.COI.2016.02.008
Bart De Goeij7
Estimated H-index: 7
(Genmab),
John M. Lambert52
Estimated H-index: 52
(ImmunoGen, Inc.)
Sources
Abstract
The clinical success of Adcetris ® (brentuximab vedotin) and Kadcyla ® (ado-trastuzumab emtansine) has sparked clinical development of novel ADCs. These powerful anti-cancer agents are designed to allow specific targeting of highly potent cytotoxic agents to tumor cells while sparing healthy tissues. Despite the use of tumor-specific antibodies, the emerging clinical data with ADCs indicates that adverse effects frequently occur before ADCs have reached their optimal therapeutic dose, resulting in a relatively narrow therapeutic window. This review summarizes the therapeutic window of ADCs currently in clinical development, along with some strategies that may help to widen the window.
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