Diet-driven interferon-γ enhances malignant transformation of primary bovine mammary epithelial cells through nutrient sensor GCN2-activated autophagy.

Published on Mar 10, 2016in Cell Death and Disease6.304
· DOI :10.1038/CDDIS.2016.48
Xiaojing Xia11
Estimated H-index: 11
(JLU: Jilin University),
Yanyi Che7
Estimated H-index: 7
(JLU: Jilin University)
+ 9 AuthorsLiancheng Lei19
Estimated H-index: 19
(JLU: Jilin University)
Sources
Abstract
Diet-driven interferon- γ enhances malignant transformation of primary bovine mammary epithelial cells through nutrient sensor GCN2-activated autophagy
📖 Papers frequently viewed together
2010
7 Authors (Li Huixia, ..., Wang Gen-lin)
3 Citations
References14
Newest
#1Xiaojing Xia (JLU: Jilin University)H-Index: 11
#2Yuanyuan Gao (JLU: Jilin University)H-Index: 5
Last. Liancheng Lei (JLU: Jilin University)H-Index: 19
view all 10 authors...
Autophagy has been linked to the regulation of both the prevention and progression of cancer. IFN-γ has been shown to induce autophagy in multiple cell lines in vitro. However, whether IFN-γ can induce autophagy and whether autophagy promotes malignant transformation in healthy lactating bovine mammary epithelial cells (BMECs) remain unclear. Here, we provide the first evidence of the correlation between IFN-γ treatment, autophagy and malignant transformation and of the mechanism underlying IFN-...
12 CitationsSource
#1Paola Maycotte (University of Colorado Denver)H-Index: 14
#2Andrew Thorburn (University of Colorado Denver)H-Index: 72
Macroautophagy (referred to as autophagy here) is an intracellular degradation pathway enhanced in response to a variety of stresses and in response to nutrient deprivation. This process provides the cell with nutrients and energy by degrading aggregated and damaged proteins as well as compromised organelles. Since autophagy has been linked to diverse diseases including cancer, it has recently become a very interesting target in breast cancer treatment. Indeed, current clinical trials are trying...
41 CitationsSource
#1Lei Quan (Roswell Park Cancer Institute)H-Index: 9
#2Zhihong Gong (Roswell Park Cancer Institute)H-Index: 22
Last. Chi Chen Hong (Roswell Park Cancer Institute)H-Index: 19
view all 17 authors...
Disparities in breast cancer biology are evident between American women of African ancestry (AA) and European ancestry (EA) and may be due, in part, to differences in immune function. To assess the potential role of constitutional host immunity on breast carcinogenesis, we tested associations between breast cancer risk and 47 single nucleotide polymorphisms (SNPs) in 26 cytokine-related genes of the adaptive immune system using 650 EA (n = 335 cases) and 864 AA (n = 458 cases) women from the Wom...
39 CitationsSource
#1Jessie Yanxiang Guo (RU: Rutgers University)H-Index: 17
#2Bing Xia (RU: Rutgers University)H-Index: 35
Last. Eileen White (RU: Rutgers University)H-Index: 109
view all 3 authors...
Mouse models for cancer are revealing novel cancer-promoting roles for autophagy. Autophagy promotes tumor growth by suppressing the p53 response, maintaining mitochondrial function, sustaining metabolic homeostasis and survival in stress, and preventing diversion of tumor progression to benign oncocytomas.
303 CitationsSource
#1Lilli B. Link (Columbia University)H-Index: 7
#2Alison J. Canchola (Cancer Prevention Institute of California)H-Index: 29
Last. Pamela L. Horn-Ross (Stanford University)H-Index: 69
view all 7 authors...
Background: Evidence that diet is associated with breast cancer risk is inconsistent. Most studies have examined risks associated with specific foods and nutrients, rather than measures of overall diet. Objective: This study aimed to evaluate dietary patterns and their relation to breast cancer risk in a large cohort of women. Design: Data from 91,779 women in the California Teachers Study cohort were analyzed, including data from 4140 women with a diagnosis of invasive breast cancer made betwee...
78 CitationsSource
Background: Breast cancer is the most commonly diagnosed cancer among women in the United States. Extensive research has been completed to evaluate the relationship between dietary factors and breast cancer risk and survival after breast cancer; however, a summary report with clinical inference is needed. Materials and Methods: This review summarizes the current epidemiological and clinical trial evidence relating diet to breast cancer incidence, recurrence, survival, and mortality. The review i...
54 CitationsSource
#1Annalisa Del Prete (University of Bari)H-Index: 24
#2Paola AllavenaH-Index: 90
Last. Alberto Mantovani (University of Milan)H-Index: 200
view all 6 authors...
: Accumulating evidence shows that chronic inflammation is associated to increased risk of cancer. An inflammatory component is present also in the microenvironment of tumours epidemiologically unrelated to inflammation. Extensive investigations over the past decade have uncovered many of the important mechanistic pathways underlying cancer-related inflammation. Pathways linking inflammation and cancer have been identified: an intrinsic one (driven by genetic events that cause neoplasia) and an ...
111 CitationsSource
Interferon-γ (IFN-γ) is a cytokine whose biological activity is conventionally associated with cytostatic/cytotoxic and antitumor mechanisms during cell-mediated adaptive immune response. It has been used clinically to treat a variety of malignancies, albeit with mixed results and side effects that can be severe. Despite ample evidence implicating a role for IFN-γ in tumor immune surveillance, there has been a steady flow of reports suggesting that it may also have pro-tumorigenic effects under ...
393 CitationsSource
A case–control study was conducted to assess the levels of α-tocopherol, retinol, and β-carotene in different tissues and the genetic expression of inflammatory mediators in women with breast cancer. The study included 51 women divided into two groups: case (n=25) and benign breast disease (n=26). We evaluated the dietary intake of α-tocopherol, retinol, and β-carotene and measured plasma and tissue concentrations of these compounds and the inflammatory mediators IL-8, IL-10, and IFNγ. The benig...
10 CitationsSource
#2Stephen G. Maher (Trinity College, Dublin)H-Index: 17
Last. Howard A. YoungH-Index: 105
view all 3 authors...
Interferon gamma (IFN-γ), a pleotropic cytokine, has been shown to be important to the function of virtually all immune cells and both innate and adaptive immune responses. In 1986, early clinical trials of this cytokine began to evaluate its therapeutic potential. The initial studies focused on the tolerability and pharmacology of IFN-γ and systematically determined its antitumor and anti-infection activities. In the 20-plus years since those first trials, IFN-γ has been used in a wide variety ...
194 CitationsSource
Cited By6
Newest
#1Qin Chen (Otto-von-Guericke University Magdeburg)H-Index: 1
#2Bo Yang (Otto-von-Guericke University Magdeburg)H-Index: 1
Last. Johannes HaybaeckH-Index: 36
view all 5 authors...
Breast carcinoma (BC) remains one of the most serious health problems. It is a heterogeneous entity, and mainly classified according to receptor status for estrogen (ER), progesterone (PR) and egf (HER2/Neu), as well as the proliferation marker ki67. Gene expression in eukaryotes is regulated at the level of both gene transcription and translation, where eukaryotic initiation factors (eIFs) are key regulators of protein biosynthesis. Aberrant translation results in an altered cellular proteome, ...
1 CitationsSource
#1Kening Xu (SDU: Shandong University)H-Index: 1
#2Lan Jin (SDU: Shandong University)H-Index: 1
Abstract IFN-γ (Interferon-gamma) is a pleiotropic cytokine. It is often involved in a variety of physiological processes by binding to the cell surface transmembrane receptor (IFN-γR) to initiate a series of signalling pathways that transmit external signals from cell surface receptors to the cell nucleus. Heparan sulphate (HS), a highly sulphated linear polysaccharide, is ubiquitous on the mammalian cell surface and extracellular matrix. Electrostatic interactions can be generated between the ...
2 CitationsSource
#1Wenbo Ren (JLU: Jilin University)H-Index: 3
#2Xiaojing XiaH-Index: 11
Last. Liancheng Lei (JLU: Jilin University)H-Index: 19
view all 7 authors...
Interferon-γ (IFN-γ) has been used to control cancers in clinical treatment. However, an increasing number of reports have suggested that in some cases effectiveness declines after a long treatment period, the reason being unclear. We have reported previously that long-term IFN-γ treatment induces malignant transformation of healthy lactating bovine mammary epithelial cells (BMECs) in vitro. In this study, we investigated the mechanisms underlying the malignant proliferation of BMECs under IFN-γ...
6 CitationsSource
#1Wenbo Ren (JLU: Jilin University)H-Index: 3
#2Yang Li (JLU: Jilin University)H-Index: 23
Last. Liancheng Lei (JLU: Jilin University)H-Index: 19
view all 13 authors...
Abstract Breast cancer is the most common female malignant tumors in the world. It seriously affects women's physical and mental health and the leading cause of cancer death among women. Our previous study demonstrated that diet-derived IFN-γ promoted the malignant transformation of primary bovine mammary epithelial cells by accelerating arginine depletion. The current study aimed to explore whether arginine addition could inhibit the degree of malignant transformation and its molecular mechanis...
4 CitationsSource
#1Xiaojing XiaH-Index: 11
#2Lei WangH-Index: 10
Last. Jianhe HuH-Index: 8
view all 12 authors...
: Traditional Chinese medicines have been recognized as especially promising anticancer agents in modern anticancer research. Halofuginone (HF), an analog of quinazolinone alkaloid extracted from Dichroa febrifuga, is widely used in traditional medicine. However, whether HF inhibits the growth of breast cancer cells and/or reduces the migration and invasion of MCF-7 human breast cancer cells, as well as the underlying mechanisms in vitro, remains unclear. In this study, we report that an HF extr...
14 CitationsSource
#1Lu HuH-Index: 3
#2Yu GaoH-Index: 4
Last. Zhitu ZhuH-Index: 5
view all 11 authors...
Arginine is one of the human nonessential amino acids critical for the growth of human cancers. The aim of this study is to investigate the variation of arginine between breast cancer (BC) patients and benign mammary gland disease (control) patients to determine its value in predicting the risk of BC. We also explore the associations between arginine levels and breast cancer subtypes. Preoperative blood samples were obtained from 267 patients (102 BC and 165 controls) in 2015. Plasma arginine va...
6 CitationsSource