Human PIEZO1 Ion Channel Functions as a Split Protein
Abstract
PIEZO1 is a mechanosensitive eukaryotic cation-selective channel that rapidly inactivates in a voltage-dependent manner. We previously showed that a fluorescent null could be encoded within the hPIEZO1 sequence without loss of function. In this work, we null the channel into two at this site and asked if coexpression would produce a functional channel or whether gating and permeation might be contained in either segment. The null null was...
Paper Details
Title
Human PIEZO1 Ion Channel Functions as a Split Protein
Published Date
Mar 10, 2016
Journal
Volume
11
Issue
3
Pages
e0151289 - e0151289
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