Autophagy is associated with cucurbitacin D-induced apoptosis in human T cell leukemia cells

Volume: 33, Issue: 4
Published: Feb 25, 2016
Abstract
We previously reported that the inflammasome inhibitor cucurbitacin D (CuD) induces apoptosis in human leukemia cell lines. In the present study, we investigated the effects of co-treatment with an additional Bcl-xL inhibitor, Z36. Treatment with Z36 induced cell death in leukemia cell lines, with MT-4 cells exhibiting the lowest sensitivity to Z36. Co-treatment of cells with Z36 and CuD resulted in a greater degree of cell death for Hut78 and...
Paper Details
Title
Autophagy is associated with cucurbitacin D-induced apoptosis in human T cell leukemia cells
Published Date
Feb 25, 2016
Volume
33
Issue
4
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