Cholestasis in Preterm Infants

Published on Jun 1, 2016in Clinics in Perinatology3.43
· DOI :10.1016/J.CLP.2016.01.012
Katie Satrom3
Estimated H-index: 3
(UMN: University of Minnesota),
Glenn R. Gourley19
Estimated H-index: 19
(UMN: University of Minnesota)
Sources
Abstract
Cholestasis in preterm infants has a multifactorial etiology. Risk factors include degree of prematurity, lack of enteral feeding, intestinal injury, prolonged use of parenteral nutrition (PN), and sepsis. Soy-based parenteral lipid emulsions have been implicated in the pathophysiology of PN-associated liver injury. Inflammation plays an important role. Medical therapies are used; however, their effects have not consistently proven effective. Evaluation of cholestasis involves laboratory work; direct bilirubin levels are used for diagnosis and trending. Adverse outcomes include risk for hepatobiliary dysfunction, irreversible liver failure, and death. Early enteral feedings as tolerated is the best way to prevent and manage cholestasis.
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References106
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#1Mette V. Østergaard (UCPH: University of Copenhagen)H-Index: 14
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#1Orly Levit (Yale University)H-Index: 6
#2Kara L. Calkins (UCLA: University of California, Los Angeles)H-Index: 11
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Background: Premature infants depend on intravenous fat emulsions to supply essential fatty acids and calories. The dose of soybean-based intravenous fat emulsions (S-IFE) has been associated with parenteral nutrition (PN)–associated liver disease. This study’s purpose was to determine if low-dose S-IFE is a safe and effective preventive strategy for cholestasis in preterm neonates. Materials and Methods: This is a multicenter randomized controlled trial in infants with a gestational age (GA) ≀2...
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#1Jemma Cleminson (Ebor: University of York)H-Index: 7
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#1Way Seah Lee (UM: University of Malaya)H-Index: 19
#2Ronald J. Sokol (University of Colorado Denver)H-Index: 95
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