Deglycosylated bleomycin has the antitumor activity of bleomycin without pulmonary toxicity
Abstract
Bleomycin (BLM) is a potent anticancer drug used to treat different malignancies, mainly lymphomas, germ cell tumors, and melanomas. Unfortunately, BLM has major, dose-dependent, pulmonary toxicity that affects 20% of treated individuals. The most severe form of BLM-induced pulmonary toxicity is lung fibrosis. Deglyco-BLM is a molecule derived from BLM in which the sugar residue d-mannosyl-l-glucose disaccharide has been deleted. The objective...
Paper Details
Title
Deglycosylated bleomycin has the antitumor activity of bleomycin without pulmonary toxicity
Published Date
Feb 17, 2016
Volume
8
Issue
326
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