Abstract 20170: Plasma Apolipoprotein C-III Levels Correlate With Malignant HDL-Lipid Composition Associated With Coronary Artery Disease in Primary Dyslipidemia

APOC3 has been focused as an emerging therapeutic target beyond LDL. ApoC-III circulates in blood on TG-rich lipoprotein and also on HDL. ApoC-III inhibits LPL activity that is essential for HDL maturation. We investigated the roles of plasma apoC-III on HDL-lipid composition beyond simple HDL-C. Methods: Fasting lipid profiles without lipid drugs were analyzed by ultracentrifugation, and free cholesterol (FC), cholesterol ester (CE),...