The prokineticin Bv8 sensitizes cutaneous terminals of female mice to heat

Background Injection of the noxious peptide Bv8 has previously been shown to induce a biphasic thermal hyperalgesia in rodents, the first peak presumably due to peripheral sensitization. This hypothesis has never been directly confirmed. We have assessed whether Bv8 can indeed sensitize peripheral nerve fibres in the mouse to heat. Methods We used recordings from single cutaneous fibres, cutaneous calcitonin gene‐related peptide (CGRP) release...