Preparation and properties of valdecoxib-hydroxypropyl beta-cyclodextrin inclusion complex.

Volume: 61, Issue: 3, Pages: 175 - 182
Published: May 1, 2007
Abstract
Valdecoxib is a non-steroidal anti-inflammatory drug used in the treatment of rheumatoid and osteoarthritis. It is practically insoluble in water. Incidence of adverse events such as nausea has been reported in some trials. Therefore, an attempt was made to improve the aqueous solubility of the drug by making an inclusion complex using hydroxypropyl beta-cyclodextrin (HPbeta-CD). The complexes were prepared by physical mixture and freeze-drying...
Paper Details
Title
Preparation and properties of valdecoxib-hydroxypropyl beta-cyclodextrin inclusion complex.
Published Date
May 1, 2007
Volume
61
Issue
3
Pages
175 - 182
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