BAG3 regulates contractility and Ca2 + homeostasis in adult mouse ventricular myocytes

Volume: 92, Pages: 10 - 20
Published: Mar 1, 2016
Abstract
Bcl2-associated athanogene 3 (BAG3) is a 575 amino acid anti-apoptotic protein that is constitutively expressed in the heart. BAG3 mutations, including mutations leading to loss of protein, are associated with familial cardiomyopathy. Furthermore, BAG3 levels have been found to be reduced in end-stage non-familial failing myocardium. In contrast to neonatal myocytes in which BAG3 is found in the cytoplasm and involved in protein quality control...
Paper Details
Title
BAG3 regulates contractility and Ca2 + homeostasis in adult mouse ventricular myocytes
Published Date
Mar 1, 2016
Volume
92
Pages
10 - 20
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