Fisetin protects liver from binge alcohol-induced toxicity by mechanisms including inhibition of matrix metalloproteinases (MMPs) and oxidative stress
Abstract
Alcohol consumption is an addictive disorder causing hepatic steatosis, fibrosis and cirrhosis. The protective effect of fisetin, a bioflavonoid, present in foods like strawberries, apples, persimmons, grapes and onions was studied on murine model of acute alcohol-induced hepatotoxicity. Five doses of 50% ethanol p.o. (10 ml/kg body weight) every 12 hours was used to induce hepatotoxicity in mice. Liver function, oxidative stress, histological...
Paper Details
Title
Fisetin protects liver from binge alcohol-induced toxicity by mechanisms including inhibition of matrix metalloproteinases (MMPs) and oxidative stress
Published Date
Apr 1, 2016
Journal
Volume
22
Pages
588 - 601
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