Antinociceptive effect of a novel armed spider peptide Tx3-5 in pathological pain models in mice

Volume: 468, Issue: 5, Pages: 881 - 894
Published: Feb 22, 2016
Abstract
The venom of the Brazilian armed spider Phoneutria nigriventer is a rich source of biologically active peptides that have potential as analgesic drugs. In this study, we investigated the analgesic and adverse effects of peptide 3-5 (Tx3-5), purified from P. nigriventer venom, in several mouse models of pain. Tx3-5 was administered by intrathecal injection to mice selected as models of postoperative (plantar incision), neuropathic (partial...
Paper Details
Title
Antinociceptive effect of a novel armed spider peptide Tx3-5 in pathological pain models in mice
Published Date
Feb 22, 2016
Volume
468
Issue
5
Pages
881 - 894
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