Longitudinal Brain Changes Associated with Prophylactic Cranial Irradiation in Lung Cancer

IntroductionThe toxic effects of prophylactic cranial irradiation (PCI) and platinum-based chemotherapy on cognition in the lung cancer population have not yet been well established. In the present study we examined the longitudinal neuropsychological and brain structural changes observed in patients with lung cancer who were undergoing these treatments.MethodsTwenty-two patients with small cell lung cancer (SCLC) who underwent platinum-based...