Mechanisms of Bronchial Hyperresponsiveness in Occupational Asthma due to Isocyanates

Published on Jan 1, 1990
路 DOI :10.1159/000417650
D Talini13
Estimated H-index: 13
Barbara Vagaggini29
Estimated H-index: 29
+ 3 AuthorsFl Dente19
Estimated H-index: 19
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The purpose of this study was to evaluate the health state of patients withoccupational asthma after cessation of occupational exposure to bakery allergens. Afollow-up study of 56 subjects with occupational asthma was carried out. Subjectswere examined twice: 1-6 months after removal from occupational exposure and 36or 48 months later. Clinical state analysis both at diagnosis and re-examlnation wasperformed with the use of a questionnaire. Functional spirometrlc tests and skin pricktests and/or...
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Several studies on the prognosis of occupational asthma have shown that a significant proportion of patients continue to experience asthmatic symptoms and nonspecific bronchial hyperresponsiveness after cessation of work. The determinants of this unfavourable prognosis of asthma are: long duration of exposure before the onset of asthma; long duration of symptoms before diagnosis; baseline airway obstruction; dual response after specific challenge test; and the persistence of markers of airway in...
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