Restoration of Nrf2 Signaling Normalizes the Regenerative Niche
Abstract
Chronic hyperglycemia impairs intracellular redox homeostasis and contributes to impaired diabetic tissue regeneration. The Keap1/Nrf2 pathway is a critical regulator of the endogenous antioxidant response system, and its dysfunction has been implicated in numerous pathologies. Here we characterize the effect of chronic hyperglycemia on Nrf2 signaling within a diabetic cutaneous regeneration model. We characterized the effects of chronic...
Paper Details
Title
Restoration of Nrf2 Signaling Normalizes the Regenerative Niche
Published Date
Dec 8, 2015
Journal
Volume
65
Issue
3
Pages
633 - 646
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