MicroRNA-Detargeted Mengovirus for Oncolytic Virotherapy
Abstract
Mengovirus, a member of the Picornaviridae family, has a broad cell tropism and can cause encephalitis and myocarditis in multiple mammalian species. Attenuation has been achieved by shortening the polycytidine tract in the 5′ noncoding region (NCR). A poly(C)-truncated strain of mengovirus, vMC 24 , resulted in significant tumor regression in immunocompetent BALB/c mice bearing syngeneic MPC-11 plasmacytomas, but the associated toxicities were...
Paper Details
Title
MicroRNA-Detargeted Mengovirus for Oncolytic Virotherapy
Published Date
Apr 15, 2016
Journal
Volume
90
Issue
8
Pages
4078 - 4092
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Notes
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