Interstitial fluid pressure regulates collective invasion in engineered human breast tumorsviaSnail, vimentin, and E-cadherin
Abstract
Many solid tumors exhibit elevated interstitial fluid pressure (IFP). This elevated pressure within the core of the tumor results in outward flow of interstitial fluid to the tumor periphery. We previously found that the directionality of IFP gradients modulates collective invasion from the surface of patterned three-dimensional (3D) aggregates of MDA-MB-231 human breast cancer cells. Here, we used this 3D engineered tumor model to investigate...
Paper Details
Title
Interstitial fluid pressure regulates collective invasion in engineered human breast tumorsviaSnail, vimentin, and E-cadherin
Published Date
Feb 8, 2016
Journal
Volume
8
Issue
3
Pages
319 - 331
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