The genetic landscape of Alzheimer disease: clinical implications and perspectives
Abstract
The search for the genetic factors contributing to Alzheimer disease (AD) has evolved tremendously throughout the years. It started from the discovery of fully penetrant mutations in Amyloid precursor protein, Presenilin 1, and Presenilin 2 as a cause of autosomal dominant AD, the identification of the ɛ4 allele of Apolipoprotein E as a strong genetic risk factor for both early-onset and late-onset AD, and evolved to the more recent detection of...
Paper Details
Title
The genetic landscape of Alzheimer disease: clinical implications and perspectives
Published Date
May 1, 2016
Journal
Volume
18
Issue
5
Pages
421 - 430
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Notes
History