Regulation of germinal center B‐cell differentiation

Summary Germinal centers (GC) are the main sites where antigen‐activated B‐cell clones expand and undergo immunoglobulin gene hypermutation and selection. Iterations of this process will lead to affinity maturation, replicating Darwinian evolution on the cellular level. GC B‐cell selection can lead to four different outcomes: further expansion and evolution, apoptosis (non‐selection), or output from the GC with differentiation into memory B...