Molecular targeted photoimmunotherapy for HER2-positive human gastric cancer in combination with chemotherapy results in improved treatment outcomes through different cytotoxic mechanisms

Published on Jan 25, 2016in BMC Cancer3.15
· DOI :10.1186/S12885-016-2072-0
Kimihiro Ito5
Estimated H-index: 5
(Jikei University School of Medicine),
Makoto Mitsunaga15
Estimated H-index: 15
(Jikei University School of Medicine)
+ 4 AuthorsHisao Tajiri63
Estimated H-index: 63
(Jikei University School of Medicine)
Background Photoimmunotherapy (PIT) is a novel type of molecular optical imaging-guided cancer phototherapy based on a monoclonal antibody conjugated to a photosensitizer, IR700, in combination with near-infrared (NIR) light. PIT rapidly causes target-specific cell death by inducing cell membrane damages and appears to be highly effective; however, we have previously demonstrated that tumor recurrences were eventually seen in PIT-treated mice, likely owing to inhomogeneous mAb-IR700 conjugate distribution in the tumor, thus limiting the effectiveness of PIT as a monotherapy. Here, we examined the effects of human epidermal growth factor-2 (HER2)-targeted PIT in combination with 5-fluorouracil (5-FU) compared to PIT alone for HER2-expressing human gastric cancer cells.
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