Where Do Programmed Death-1 Inhibitors Fit in the Management of Malignant Lymphoma?
Abstract
Tumor-specific cytotoxic T cells have the capacity to target and eradicate malignant B cells in patients with Hodgkin and non-Hodgkin lymphoma; however, multiple mechanisms, including regulatory T cells, immunosuppressive ligands, and immune exhaustion, suppress an effective antitumor immune response. One mechanism that is used by malignant cells to inhibit the immune response is overexpression of programmed death ligand 1 or 2 (PD-L1 or PD-L2)...
Paper Details
Title
Where Do Programmed Death-1 Inhibitors Fit in the Management of Malignant Lymphoma?
Published Date
Feb 1, 2016
Journal
Volume
12
Issue
2
Pages
101 - 106
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Notes
History