Divergent clonal selection dominates medulloblastoma at recurrence
Abstract
The development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related toxicity. We treated a transposon–driven, functional genomic mouse model of medulloblastoma with ‘humanized’ in vivo therapy (microneurosurgical tumour resection followed by multi-fractionated, image-guided radiotherapy). Genetic events in recurrent murine medulloblastoma exhibit a very poor...
Paper Details
Title
Divergent clonal selection dominates medulloblastoma at recurrence
Published Date
Jan 1, 2016
Journal
Volume
529
Issue
7586
Pages
351 - 357
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Notes
History